ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
AKR1C3	aldo-keto reductase family 1 member C3	AKR1C3	cg08894837	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AKR1D1	aldo-keto reductase family 1 member D1	AKR1D1	ENSG00000122787	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AKT1	AKT serine/threonine kinase 1	AKT1	cg18071894	Methylation	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AKT1	AKT serine/threonine kinase 1	pAKT	ENSG00000142208	Protein	None	Cardiac	Nonesvg	Cardiac	None	Heart	None	Yes	Differential expression	No	None	rs1129293	Polymorphism	Homo sapiens	Brazil	None	35870262	10.1016/j.imbio.2022.152242	Synonymous mutation rs1129293 is associated with PIK3CG expression and PI3KÎ³ activation in patients with chronic Chagas cardiomyopathy	2022
AKT2	AKT serine/threonine kinase 2	AKT2	cg27403957	Methylation	DOWN	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AKT2	AKT serine/threonine kinase 2	AKT2	cg11425201	Methylation	DOWN	Severe cardiac	LVEF < 40%svg	Moderate cardiac	LVEF >= 40%	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AKT2	AKT serine/threonine kinase 2	AKT2	cg14886198	Methylation	DOWN	Severe cardiac	LVEF < 40%svg	Moderate cardiac	LVEF >= 40%	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AL109767.1	novel transcript	AL109767.1	ENSG00000235785	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AL122127.25	novel transcript	AL122127.25	ENSG00000244620	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AL122127.3	novel transcript	AL122127.3	ENSG00000265714	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AL133458.1	novel transcript	AL133458.1	ENSG00000197146	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AL365331.2	VDAC2 pseudogene 3	AL365331.2	ENSG00000213262	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AL592188.3	novel transcript	AL592188.3	ENSG00000263806	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
AL928768.3	novel transcript	AL928768.3	ENSG00000253701	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
ALAS1	5'-aminolevulinate synthase 1	ALAS1	cg22988305	Methylation	DOWN	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
ALAS1	5'-aminolevulinate synthase 1	ALAS1	cg03820136	Methylation	DOWN	Severe cardiac	LVEF < 40%svg	Moderate cardiac	LVEF >= 40%	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
ALAS1	5'-aminolevulinate synthase 1	ALAS1	cg22988305	Methylation	DOWN	Severe cardiac	LVEF < 40%svg	Moderate cardiac	LVEF >= 40%	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
ALCAM	activated leukocyte cell adhesion molecule	ALCAM	cg06648780	Methylation	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
ALCAM	activated leukocyte cell adhesion molecule	ALCAM	cg24685239	Methylation	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
ALDH16A1	aldehyde dehydrogenase 16 family member A1	ALDH16A1	cg03199887	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022

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