Welcome to ChagasDB!

Chagas disease is a parasitical disease caused by Trypanosoma cruzi, a protozoan endemic from south America. This parasite can infect many mammals, like domestic dogs, raccoons, or humans. It is mostly asymptomatic, but it can lead to several complications in 30-40% of infected patients, notably cardiac, but also digestive, cardiodigestive or nervous.

ChagasDB is a manual-curated database regrouping published results referenced in Pubmed. For now, it gathers all the molecules significantly associated with T.cruzi infection in different host species, including genes, proteins, polymorphisms, hormones, or other chemical compounds. Simplified access to all this information is intended to improve the understanding of chagas disease, and thus facilitate the search for a treatment.

ChagasDB allow you to search specific features in different organisms, infected with different T.cruzi strains.
You can also download the whole database. Find a user guide in the Guide tab.

Last update: 31/05/2023

Citing ChagasDB:
Brochet P, Mouren JC, Hannouche L, Lopez F, Ballester B, Cunha-Neto E, Spinelli L, Chevillard C. ChagasDB: 80 years of publicly available data on the molecular host response to Trypanosoma cruzi infection in a single database. Database (Oxford). 2023 May 23;2023:baad037. doi: 10.1093/database/baad037. PMID: 37221041.

ChagasDB GitHub:
Papers citing ChagasDB:
  • Futur paper 1
  • Futur paper 2
  • Futur paper 3