ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Il6st	interleukin 6 cytokine family signal transducer [Source:RGD Symbol;Acc:2903]	gp130	ENSRNOG00000013963	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9657259	10.1016/s0165-2478(97)00167-3	Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy	1998
Il6st	interleukin 6 cytokine family signal transducer [Source:RGD Symbol;Acc:2903]	gp130	ENSRNOG00000013963	Protein	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9657259	10.1016/s0165-2478(97)00167-3	Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy	1998
Nos2	nitric oxide synthase 2 [Source:RGD Symbol;Acc:3185]	iNOS	ENSRNOG00000057443	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998
Nos2	nitric oxide synthase 2 [Source:RGD Symbol;Acc:3185]	iNOS	ENSRNOG00000057443	Protein	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998
Tnf	tumor necrosis factor [Source:RGD Symbol;Acc:3876]	TNF-Î±	ENSRNOG00000070745	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998
Tnf	tumor necrosis factor [Source:RGD Symbol;Acc:3876]	TNF-Î±	ENSRNOG00000070745	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998
Alkalinephosphatase	None	Alkaline phosphatase	None	Protein	UP	Severe cardiac	Nonesvg	Healthy	None	PBMC	Coronary	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
IFNÎ³	interferon gamma	IFNÎ³	ENSG00000111537	RNA	UP	Chronic	Nonesvg	Healthy	None	PBMC	None	Yes	RT-PCR	No	None	None	None	Homo sapiens	Brazil	None	9010503	10.1046/j.1365-3083.1997.d01-362.x	Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection	1997
IL-10	interleukin 10	IL-10	ENSG00000136634	RNA	UP	Chronic	Nonesvg	Healthy	None	PBMC	None	Yes	RT-PCR	No	None	None	None	Homo sapiens	Brazil	None	9010503	10.1046/j.1365-3083.1997.d01-362.x	Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection	1997
IL-13	interleukin 13	IL-13	ENSG00000169194	RNA	UP	Chronic	Nonesvg	Healthy	None	PBMC	None	Yes	RT-PCR	No	None	None	None	Homo sapiens	Brazil	None	9010503	10.1046/j.1365-3083.1997.d01-362.x	Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection	1997
IL-5	interleukin 5	IL-5	ENSG00000113525	RNA	UP	Chronic	Nonesvg	Healthy	None	PBMC	None	Yes	RT-PCR	No	None	None	None	Homo sapiens	Brazil	None	9010503	10.1046/j.1365-3083.1997.d01-362.x	Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection	1997
Inorganicphosphate	Inorganic phosphate	Inorganic phosphate	None	Electrolyte	UP	Asymptomatic	Nonesvg	Healthy	None	PBMC	Coronary	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Inorganicphosphate	Inorganic phosphate	Inorganic phosphate	None	Electrolyte	UP	Moderate cardiac	Nonesvg	Healthy	None	PBMC	Coronary	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Inorganicphosphate	Inorganic phosphate	Inorganic phosphate	None	Electrolyte	UP	Moderate cardiac	Nonesvg	Healthy	None	PBMC	Systemic	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Inorganicphosphate	Inorganic phosphate	Inorganic phosphate	None	Electrolyte	UP	Severe cardiac	Nonesvg	Healthy	None	PBMC	Coronary	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Inorganicphosphate	Inorganic phosphate	Inorganic phosphate	None	Electrolyte	UP	Severe cardiac	Nonesvg	Healthy	None	PBMC	Systemic	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Isocitratedehydrogenase	None	Isocitrate dehydrogenase	None	Protein	UP	Severe cardiac	Nonesvg	Healthy	None	PBMC	Coronary	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Mucoproteins	None	Mucoproteins	None	Protein	UP	Asymptomatic	Nonesvg	Healthy	None	PBMC	Peripheric vein	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Mucoproteins	None	Mucoproteins	None	Protein	UP	Moderate cardiac	Nonesvg	Healthy	None	PBMC	Peripheric vein	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997
Mucoproteins	None	Mucoproteins	None	Protein	UP	Severe cardiac	Nonesvg	Healthy	None	PBMC	Coronary	Yes	Measurement	No	None	None	None	Homo sapiens	Venezuela	None	9377823	10.1002/clc.4960201013	Biochemical characterization of myocardial damage in chronic chagas' disease	1997

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