ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Il24	interleukin 24 [Source:RGD Symbol;Acc:621484]	MDA	ENSRNOG00000004470	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	NA	Yes	Standard curve	No	None	None	None	Rattus norvegicus	Lewis rats	None	10886247	10.1046/j.1365-2249.2000.01258.x	Differential regulation of nitric oxide synthase isoforms in experimental acute Chagasic cardiomyopathy	2000
LFA-1	integrin subunit alpha L	LFA-1	ENSG00000005844	Protein	UP	Cardiac	Nonesvg	Healthy	None	Heart	Endothelial & interstitial cells	Yes	Immunohistochemical expression	No	None	None	None	Homo sapiens	None	None	10867361	10.1016/s1054-8807(00)00027-2	Upregulation of Adhesion Molecules and Class I HLA in the Myocardium of Chronic Chagasic Cardiomyopathy and Heart Allograft Rejection, But Not in Dilated Cardiomyopathy	2000
Nos2	nitric oxide synthase 2 [Source:RGD Symbol;Acc:3185]	NOS2	ENSRNOG00000057443	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	NA	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	10886247	10.1046/j.1365-2249.2000.01258.x	Differential regulation of nitric oxide synthase isoforms in experimental acute Chagasic cardiomyopathy	2000
Nos2	nitric oxide synthase 2 [Source:RGD Symbol;Acc:3185]	NOS2	ENSRNOG00000057443	Protein	UP	Acute	Nonesvg	Healthy	None	Heart	NA	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	10886247	10.1046/j.1365-2249.2000.01258.x	Differential regulation of nitric oxide synthase isoforms in experimental acute Chagasic cardiomyopathy	2000
Nos3	nitric oxide synthase 3 [Source:RGD Symbol;Acc:3186]	NOS3	ENSRNOG00000009348	Protein	UP	Acute	Nonesvg	Healthy	None	Heart	NA	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	10886247	10.1046/j.1365-2249.2000.01258.x	Differential regulation of nitric oxide synthase isoforms in experimental acute Chagasic cardiomyopathy	2000
VCAM-1	vascular cell adhesion molecule 1	VCAM-1	ENSG00000162692	Protein	UP	Cardiac	Nonesvg	Healthy	None	Heart	Endothelial & interstitial cells	Yes	Immunohistochemical expression	No	None	None	None	Homo sapiens	None	None	10867361	10.1016/s1054-8807(00)00027-2	Upregulation of Adhesion Molecules and Class I HLA in the Myocardium of Chronic Chagasic Cardiomyopathy and Heart Allograft Rejection, But Not in Dilated Cardiomyopathy	2000
IL-12	interleukin 12B	IL-12	ENSG00000113302	Protein	DOWN	Acute	Nonesvg	Healthy	None	PBMC	Dendritic cell	Yes	ELISA	No	None	None	None	Homo sapiens	None	Tehuantepec	10417171	10.1128/iai.67.8.4033-4040.1999	Trypanosoma cruzi Infects Human Dendritic Cells and Prevents Their Maturation: Inhibition of Cytokines, HLA-DR, And Costimulatory Molecules	1999
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF	ENSMUSG00000024401	Protein	UP	Acute	Nonesvg	Healthy	None	Plasma	None	Yes	ELISA	No	None	None	None	Mus musculus	BALB/c	Tehuantepec	10531203	10.1128/iai.67.11.5579-5586.1999	The Endogenous Balance of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely Infected with Trypanosoma cruzi	1999
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF	ENSMUSG00000024401	Protein	UP	Chronic	Nonesvg	Healthy	None	Plasma	None	Yes	ELISA	No	None	None	None	Mus musculus	BALB/c	Tehuantepec	10531203	10.1128/iai.67.11.5579-5586.1999	The Endogenous Balance of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely Infected with Trypanosoma cruzi	1999
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a [Source:MGI Symbol;Acc:MGI:1314884]	sTNFR1	ENSMUSG00000030341	Protein	UP	Acute	Nonesvg	Healthy	None	Plasma	None	Yes	ELISA	No	None	None	None	Mus musculus	BALB/c	Tehuantepec	10531203	10.1128/iai.67.11.5579-5586.1999	The Endogenous Balance of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely Infected with Trypanosoma cruzi	1999
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a [Source:MGI Symbol;Acc:MGI:1314884]	sTNFR1	ENSMUSG00000030341	Protein	UP	Chronic	Nonesvg	Healthy	None	Plasma	None	Yes	ELISA	No	None	None	None	Mus musculus	BALB/c	Tehuantepec	10531203	10.1128/iai.67.11.5579-5586.1999	The Endogenous Balance of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely Infected with Trypanosoma cruzi	1999
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b [Source:MGI Symbol;Acc:MGI:1314883]	sTNFR2	ENSMUSG00000028599	Protein	UP	Acute	Nonesvg	Healthy	None	Plasma	None	Yes	ELISA	No	None	None	None	Mus musculus	BALB/c	Tehuantepec	10531203	10.1128/iai.67.11.5579-5586.1999	The Endogenous Balance of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely Infected with Trypanosoma cruzi	1999
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b [Source:MGI Symbol;Acc:MGI:1314883]	sTNFR2	ENSMUSG00000028599	Protein	UP	Chronic	Nonesvg	Healthy	None	Plasma	None	Yes	ELISA	No	None	None	None	Mus musculus	BALB/c	Tehuantepec	10531203	10.1128/iai.67.11.5579-5586.1999	The Endogenous Balance of Soluble Tumor Necrosis Factor Receptors and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely Infected with Trypanosoma cruzi	1999
TNF-Î±	tumor necrosis factor	TNF-Î±	ENSG00000232810	Protein	DOWN	Acute	Nonesvg	Healthy	None	PBMC	Dendritic cell	Yes	ELISA	No	None	None	None	Homo sapiens	None	Tehuantepec	10417171	10.1128/iai.67.8.4033-4040.1999	Trypanosoma cruzi Infects Human Dendritic Cells and Prevents Their Maturation: Inhibition of Cytokines, HLA-DR, And Costimulatory Molecules	1999
Ctf1	cardiotrophin 1 [Source:RGD Symbol;Acc:2442]	CT-1	ENSRNOG00000018962	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9657259	10.1016/s0165-2478(97)00167-3	Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy	1998
Ctf1	cardiotrophin 1 [Source:RGD Symbol;Acc:2442]	CT-1	ENSRNOG00000018962	Protein	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9657259	10.1016/s0165-2478(97)00167-3	Overexpression of cardiotrophin-1 and gp130 during experimental acute Chagasic cardiomyopathy	1998
Il1b	interleukin 1 beta [Source:RGD Symbol;Acc:2891]	IL-1Î²	ENSRNOG00000004649	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998
Il1b	interleukin 1 beta [Source:RGD Symbol;Acc:2891]	IL-1Î²	ENSRNOG00000004649	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998
Il6	interleukin 6 [Source:RGD Symbol;Acc:2901]	IL-6	ENSRNOG00000010278	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998
Il6	interleukin 6 [Source:RGD Symbol;Acc:2901]	IL-6	ENSRNOG00000010278	RNA	UP	Acute	Nonesvg	Healthy	None	Heart	None	Yes	Western blot	No	None	None	None	Rattus norvegicus	Lewis rats	None	9546353	NA	Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy	1998

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