ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
TNF	TNF superfamily member 8	TNF-a	ENSG00000106952	Protein	UP	Chagas	Nonesvg	Healthy	None	Plasma	None	Yes	High sensitivity Quantikine HS	No	None	None	None	Homo sapiens	Brazil	None	12886425	10.1590/s0074-02762003000300021	Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/indeterminate and Chagas disease cardiomyopathy patients	2003
TNF	TNF superfamily member 8	TNF-a	ENSG00000106952	Protein	UP	Severe cardiac	EF <= 0.5svg	Moderate cardiac	EF > 0.5	Plasma	NA	Yes	High sensitivity Quantikine HS	No	None	None	None	Homo sapiens	Brazil	None	12886425	10.1590/s0074-02762003000300021	Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/indeterminate and Chagas disease cardiomyopathy patients	2003
Tnfaip2	None	Tumor necrosis factor induced protein 2 (TNFIP2)	ENSMUSG00000021281	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnfaip2	None	Tumor necrosis factor induced protein 2 (TNFIP2)	ENSMUSG00000021281	RNA	UP	Acute	3 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnfaip2	None	Tumor necrosis factor induced protein 2 (TNFIP2)	ENSMUSG00000021281	RNA	UP	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnf-relatedapoptosisinducingligand(trail)	None	TNF-related apoptosis inducing ligand (TRAIL)	None	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnf-relatedapoptosisinducingligand(trail)	None	TNF-related apoptosis inducing ligand (TRAIL)	None	RNA	UP	Acute	3 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnfrsf1a	None	Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	ENSMUSG00000030341	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnfrsf1a	None	Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	ENSMUSG00000030341	RNA	UP	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnnc2	troponin C2, fast [Source:MGI Symbol;Acc:MGI:98780]	Fast skeletal troponin C (FskTnC)	ENSMUSG00000017300	RNA	DOWN	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Tnnt1	troponin T2, cardiac [Source:MGI Symbol;Acc:MGI:104597]	Cardiac troponin T2 (cTnT2)	ENSMUSG00000026414	RNA	DOWN	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Se	Se	Se	None	Chemical molecule	DOWN	Cardiac	Nonesvg	Healthy	None	Serum	NA	Yes	Atomic absorption spectrometry	No	None	None	None	Homo sapiens	Brazil	None	12055254	10.4049/jimmunol.168.12.6366	The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection	2002
Se	Se	Se	None	Chemical molecule	DOWN	Chagas	Nonesvg	Healthy	None	Serum	NA	Yes	Atomic absorption spectrometry	No	None	None	None	Homo sapiens	Brazil	None	12055254	10.4049/jimmunol.168.12.6366	The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection	2002
Se	Se	Se	None	Chemical molecule	DOWN	Digestive	Megasyndromessvg	Healthy	None	Serum	NA	Yes	Atomic absorption spectrometry	No	None	None	None	Homo sapiens	Bolivia	None	12055254	10.4049/jimmunol.168.12.6366	The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection	2002
Se	Se	Se	None	Chemical molecule	DOWN	Indeterminate	Nonesvg	Healthy	None	Serum	NA	Yes	Atomic absorption spectrometry	No	None	None	None	Homo sapiens	Brazil	None	12055254	10.4049/jimmunol.168.12.6366	The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection	2002
TGFB1	transforming growth factor beta 1	TGF-Î²1	ENSG00000105329	Protein	UP	Cardiac	Card1svg	Healthy	None	Serum	NA	Yes	ELISA	No	None	None	None	Homo sapiens	Brazil	None	12447769	10.1086/345882	Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy	2002
TGFB1	transforming growth factor beta 1	TGF-Î²1	ENSG00000105329	Protein	UP	Cardiac	Card2svg	Healthy	None	Serum	NA	Yes	ELISA	No	None	None	None	Homo sapiens	Brazil	None	12447769	10.1086/345882	Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy	2002
TGFB1	transforming growth factor beta 1	TGF-Î²1	ENSG00000105329	Protein	UP	Indeterminate	Nonesvg	Healthy	None	Serum	NA	Yes	ELISA	No	None	None	None	Homo sapiens	Brazil	None	12447769	10.1086/345882	Implication of transforming growth factor-beta1 in Chagas disease myocardiopathy	2002
CCR5	C-C motif chemokine receptor 5	CCR5 59029 G	None	Polymorphism	DOWN	Cardiac	Nonesvg	Asymptomatic	None	PBMC	NA	Yes	PCR	No	None	None	None	Homo sapiens	Peru	None	11703822	10.1034/j.1399-0039.2001.580302.x	Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy	2001
CCR5	C-C motif chemokine receptor 5	CCR5 59029-A/G	None	Polymorphism	DOWN	Cardiac	Nonesvg	Asymptomatic	None	PBMC	NA	Yes	PCR	No	None	None	None	Homo sapiens	Peru	None	11703822	10.1034/j.1399-0039.2001.580302.x	Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy	2001

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