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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Irf8	interferon regulatory factor 8 [Source:MGI Symbol;Acc:MGI:96395]	Interferon concensus sequence binding protein	ENSMUSG00000041515	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Junzipper-associated1protein	None	Jun zipper-associated 1 protein	None	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Junzipper-associated1protein	None	Jun zipper-associated 1 protein	None	RNA	UP	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Mitogen-activatedproteinkinasekinase1(mapkk1)	None	Mitogen-activated protein kinase kinase 1 (MAPKK1)	None	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Mitogen-activatedproteinkinasekinase1(mapkk1)	None	Mitogen-activated protein kinase kinase 1 (MAPKK1)	None	RNA	UP	Acute	3 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Myh6	myosin heavy chain 6 [Source:RGD Symbol;Acc:62029]	myosin heavy chain Î± (MyHCÎ±)	ENSRNOG00000025757	RNA	UP	Acute	8h pisvg	Healthy	None	Cardiomyocytes	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Dawley rats	Y strain	12874323	10.1128/IAI.71.8.4441-4447.2003	Role for Interleukin-1 beta in Trypanosoma cruzi-Induced Cardiomyocyte Hypertrophy	2003
Myh6	myosin heavy chain 6 [Source:RGD Symbol;Acc:62029]	myosin heavy chain Î± (MyHCÎ±)	ENSRNOG00000025757	RNA	UP	Acute	24h pisvg	Healthy	None	Cardiomyocytes	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Dawley rats	Y strain	12874323	10.1128/IAI.71.8.4441-4447.2003	Role for Interleukin-1 beta in Trypanosoma cruzi-Induced Cardiomyocyte Hypertrophy	2003
Myh7	myosin heavy chain 7 [Source:RGD Symbol;Acc:62030]	myosin heavy chain Î² (MyHCÎ²)	ENSRNOG00000016983	RNA	UP	Acute	24h pisvg	Healthy	None	Cardiomyocytes	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Dawley rats	Y strain	12874323	10.1128/IAI.71.8.4441-4447.2003	Role for Interleukin-1 beta in Trypanosoma cruzi-Induced Cardiomyocyte Hypertrophy	2003
Ndufa1	NADH:ubiquinone oxidoreductase subunit A1 [Source:MGI Symbol;Acc:MGI:1929511]	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1	ENSMUSG00000016427	RNA	DOWN	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Nppb	natriuretic peptide type B [Source:MGI Symbol;Acc:MGI:97368]	Atrial natriuretic peptide precursor type B (ANF)	ENSMUSG00000029019	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Nppb	natriuretic peptide type B [Source:MGI Symbol;Acc:MGI:97368]	Atrial natriuretic peptide precursor type B (ANF)	ENSMUSG00000029019	RNA	UP	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Ogn	osteoglycin [Source:MGI Symbol;Acc:MGI:109278]	Osteoglycin	ENSMUSG00000021390	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Ogn	osteoglycin [Source:MGI Symbol;Acc:MGI:109278]	Osteoglycin	ENSMUSG00000021390	RNA	DOWN	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Peripheralbenzodiazepinereceptor(pbdzr)	None	Peripheral benzodiazepine receptor (PBdzR)	None	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Saa3	serum amyloid A 3 [Source:MGI Symbol;Acc:MGI:98223]	Serum amyloid A 3	ENSMUSG00000040026	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Smallinduciblecytokinea2(scy2)	None	Small inducible cytokine A2 (SCY2)	None	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Spn	sialophorin [Source:MGI Symbol;Acc:MGI:98384]	Sialophorin	ENSMUSG00000051457	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Thbs2	thrombospondin 2 [Source:MGI Symbol;Acc:MGI:98738]	Thrombospondin 2 (THMB2)	ENSMUSG00000023885	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Thbs2	thrombospondin 2 [Source:MGI Symbol;Acc:MGI:98738]	Thrombospondin 2 (THMB2)	ENSMUSG00000023885	RNA	UP	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
TNF	TNF superfamily member 8	TNF-a	ENSG00000106952	Protein	UP	Cardiac	Nonesvg	Asymptomatic	None	Plasma	NA	Yes	High sensitivity Quantikine HS	No	None	None	None	Homo sapiens	Brazil	None	12886425	10.1590/s0074-02762003000300021	Increased plasma levels of tumor necrosis factor-alpha in asymptomatic/indeterminate and Chagas disease cardiomyopathy patients	2003

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