ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
CXCR4	C-X-C motif chemokine receptor 4	CXCR4	ENSG00000121966	Protein	DOWN	Severe cardiac	Nonesvg	Mild cardiac	None	PBMC	CD4+	Yes	Fluorescence	No	None	None	None	Homo sapiens	Brazil	None	14722885	10.1086/380803	Chemokine receptor expression on the surface of peripheral blood mononuclear cells in Chagas disease	2004
CXCR4	C-X-C motif chemokine receptor 4	CXCR4	ENSG00000121966	Protein	DOWN	Severe cardiac	Nonesvg	Mild cardiac	None	PBMC	CD8+	Yes	Fluorescence	No	None	None	None	Homo sapiens	Brazil	None	14722885	10.1086/380803	Chemokine receptor expression on the surface of peripheral blood mononuclear cells in Chagas disease	2004
CXCR4	C-X-C motif chemokine receptor 4	CXCR4	ENSG00000121966	Protein	DOWN	Severe cardiac	Nonesvg	Mild cardiac	None	PBMC	CD14+	Yes	Fluorescence	No	None	None	None	Homo sapiens	Brazil	None	14722885	10.1086/380803	Chemokine receptor expression on the surface of peripheral blood mononuclear cells in Chagas disease	2004
IL10	interleukin 10	IL-10 (allele 138)	None	Polymorphism	DOWN	Chagas	Nonesvg	Healthy	None	PBMC	None	Yes	PCR	No	None	None	None	Homo sapiens	Brazil	None	15191519	10.1111/j.1399-0039.2004.00260.x	Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-11	2004
Nitrite	None	Nitrite	None	Chemical molecule	DOWN	Acute	6 dpisvg	Healthy	None	PBMC	None	Yes	Absorbance	No	None	None	None	Rattus norvegicus	Holtzman	Y strain	15491849	10.1016/j.niox.2004.07.010	Peripheral blood monocytes show morphological pattern of activation and decreased nitric oxide production during acute Chagas' disease in rats	2004
Nitrite	None	Nitrite	None	Chemical molecule	DOWN	Acute	20 dpisvg	Healthy	None	PBMC	None	Yes	Absorbance	No	None	None	None	Rattus norvegicus	Holtzman	Y strain	15491849	10.1016/j.niox.2004.07.010	Peripheral blood monocytes show morphological pattern of activation and decreased nitric oxide production during acute Chagas' disease in rats	2004
TNF	tumor necrosis factor	TNF-Î±	ENSG00000232810	Protein	UP	Severe cardiac	Nonesvg	Healthy	None	PBMC	None	Yes	ELISA	No	None	None	None	Homo sapiens	Brazil	None	15034825	10.1086/381892	Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy	2004
TNF	tumor necrosis factor	TNF-Î±	ENSG00000232810	Protein	UP	Severe cardiac	Nonesvg	Mild cardiac	None	PBMC	None	Yes	ELISA	No	None	None	None	Homo sapiens	Brazil	None	15034825	10.1086/381892	Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy	2004
Anxa2	annexin A2 [Source:MGI Symbol;Acc:MGI:88246]	Annexin A2	ENSMUSG00000032231	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Anxa2	annexin A2 [Source:MGI Symbol;Acc:MGI:88246]	Annexin A2	ENSMUSG00000032231	RNA	UP	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Atox1	antioxidant 1 copper chaperone [Source:MGI Symbol;Acc:MGI:1333855]	Anti-oxidant protein 1	ENSMUSG00000018585	RNA	UP	Acute	3 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Atox1	antioxidant 1 copper chaperone [Source:MGI Symbol;Acc:MGI:1333855]	Anti-oxidant protein 1	ENSMUSG00000018585	RNA	DOWN	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Atp2a3	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [Source:RGD Symbol;Acc:2175]	SERCA	ENSRNOG00000017912	RNA	UP	Acute	24h pisvg	Healthy	None	Cardiomyocytes	None	Yes	Northern blot	No	None	None	None	Rattus norvegicus	Dawley rats	Y strain	12874323	10.1128/IAI.71.8.4441-4447.2003	Role for Interleukin-1 beta in Trypanosoma cruzi-Induced Cardiomyocyte Hypertrophy	2003
Cardiactroponinti(ctnt1)	troponin T1, skeletal, slow [Source:MGI Symbol;Acc:MGI:1333868]	Cardiac troponin TI (cTnT1)	ENSMUSG00000064179	RNA	DOWN	Chronic	110 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Cckbr	cholecystokinin B receptor [Source:MGI Symbol;Acc:MGI:99479]	CC chemokine receptor type 2 (CCKR2)	ENSMUSG00000030898	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Ccr5	chemokine (C-C motif) receptor 5 [Source:MGI Symbol;Acc:MGI:107182]	CC chemokine receptor type 5 (CCKR5)	ENSMUSG00000079227	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Col1a1	collagen, type I, alpha 1 [Source:MGI Symbol;Acc:MGI:88467]	Procollagen 1 alpha 1 subunit (COL1A1)	ENSMUSG00000001506	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Col1a2	collagen, type I, alpha 2 [Source:MGI Symbol;Acc:MGI:88468]	Procollagen 1 alpha 2 subunit (COL1A2)	ENSMUSG00000029661	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Col3a1	collagen, type III, alpha 1 [Source:MGI Symbol;Acc:MGI:88453]	Procollagen 3 alpha 1 subunit (COL3A1)	ENSMUSG00000026043	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003
Col5a2	collagen, type V, alpha 2 [Source:MGI Symbol;Acc:MGI:88458]	Procollagen 5 alpha 2 subunit (COL5A2)	ENSMUSG00000026042	RNA	UP	Acute	37 dpisvg	Healthy	None	Myocardium	None	No	Microarray	No	None	None	None	Mus musculus	C3H/HeN	Sylvio X10/4	12853116	10.1016/s0925-4439(03)00060-7	Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development	2003

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