ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
CXCL9	C-X-C motif chemokine ligand 9	MIG	ENSG00000138755	Protein	UP	Digestive	Esophagopathysvg	Healthy	None	Blood	None	Yes	Enzyme immunoassay	No	None	None	None	Homo sapiens	Brazil	None	16513426	10.1016/j.clim.2005.12.011	Evaluation of cytokines (MIG, IFN-gamma, TNF-alpha, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy	2006
DDX39B	DExD-Box Helicase 39B	BAT1 -22C	None	Polymorphism	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	Yes	PCR	No	None	None	None	Homo sapiens	Brazil	None	16619187	10.1086/503368	BAT1, a putative anti-inflammatory gene, is associated with chronic Chagas cardiomyopathy	2006
DDX39B	DExD-Box Helicase 39B	BAT1 -348C	None	Polymorphism	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	Yes	PCR	No	None	None	None	Homo sapiens	Brazil	None	16619187	10.1086/503368	BAT1, a putative anti-inflammatory gene, is associated with chronic Chagas cardiomyopathy	2006
GPX1	glutathione peroxidase 1	GPx	ENSG00000233276	Protein	UP	Chagas	Nonesvg	Healthy	None	Blood	None	Yes	TBARS assay	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
GSS	glutathione synthetase	Glutathione	ENSG00000100983	Protein	UP	Chagas	Nonesvg	Healthy	None	Blood	None	Yes	TBARS assay	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
IFNG	interferon gamma	IFN-Î³	ENSG00000111537	Protein	UP	Digestive	Esophagopathysvg	Healthy	None	Blood	None	Yes	Enzyme immunoassay	No	None	None	None	Homo sapiens	Brazil	None	16513426	10.1016/j.clim.2005.12.011	Evaluation of cytokines (MIG, IFN-gamma, TNF-alpha, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy	2006
IL1B	interleukin 1 beta	IL1B +3954CC	None	Polymorphism	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	Yes	PCR	No	None	None	None	Homo sapiens	Colombia	None	17002905	10.1016/j.humimm.2006.06.004	Interleukin-1 Gene Cluster Polymorphism in Chagas Disease in a Colombian Case-Control Study	2006
IL1B	interleukin 1 beta	IL1B 31CC	None	Polymorphism	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	Yes	PCR	No	None	None	None	Homo sapiens	Colombia	None	17002905	10.1016/j.humimm.2006.06.004	Interleukin-1 Gene Cluster Polymorphism in Chagas Disease in a Colombian Case-Control Study	2006
IL1B	interleukin 1 beta	IL1B+5810G	None	Polymorphism	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	Yes	PCR	No	None	None	None	Homo sapiens	Colombia	None	17002905	10.1016/j.humimm.2006.06.004	Interleukin-1 Gene Cluster Polymorphism in Chagas Disease in a Colombian Case-Control Study	2006
IL1B	interleukin 1 beta	IL1B+5810GG	None	Polymorphism	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	Yes	PCR	No	None	None	None	Homo sapiens	Colombia	None	17002905	10.1016/j.humimm.2006.06.004	Interleukin-1 Gene Cluster Polymorphism in Chagas Disease in a Colombian Case-Control Study	2006
IL24	interleukin 24	MDA	ENSG00000162892	Protein	UP	Chagas	Nonesvg	Healthy	None	Plasma	None	Yes	TBARS assay	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
IL24	interleukin 24	MDA	ENSG00000162892	Protein	UP	Chagas	Nonesvg	Healthy	None	Blood	Mitochondrial	Yes	TBARS assay	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
MT-ND1	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1	ENSG00000198888	None	Protein	DOWN	Chagas	Nonesvg	Healthy	None	Blood	Mitochondrial	Yes	pyrogallol oxidation	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
SOD1	superoxide dismutase 1	SOD	ENSG00000142168	Protein	UP	Chagas	Nonesvg	Healthy	None	Blood	None	Yes	TBARS assay	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
SOD2	Superoxide Dismutase 2	MnSOD	ENSG00000291237	Protein	DOWN	Chagas	Nonesvg	Healthy	None	Blood	Mitochondrial	Yes	pyrogallol oxidation	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
TNF	tumor necrosis factor	TNF-Î±	ENSG00000232810	Protein	UP	Digestive	Esophagopathysvg	Healthy	None	Blood	None	Yes	Enzyme immunoassay	No	None	None	None	Homo sapiens	Brazil	None	16513426	10.1016/j.clim.2005.12.011	Evaluation of cytokines (MIG, IFN-gamma, TNF-alpha, IL-4, IL-5, and IL-10) during the different evolutive phases of chagasic esophagopathy	2006
UQCR11	ubiquinol-cytochrome c reductase, complex III subunit XI	Complex 3	ENSG00000127540	Protein	DOWN	Chagas	Nonesvg	Healthy	None	Blood	Mitochondrial	Yes	pyrogallol oxidation	No	None	None	None	Homo sapiens	None	None	16814107	10.1016/j.freeradbiomed.2006.04.009	Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients	2006
ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group)	ATP-binding cassette, sub-family B , member 6 (ABCB6), nuclear gene encoding mitochondrial protein	ENSG00000115657	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	None	No	Microarray	No	None	None	None	Homo sapiens	Brazil	None	16049318	10.1016/S0002-9440(10)62976-8	Cardiac Gene Expression Profiling Provides Evidence for Cytokinopathy as a Molecular Mechanism in Chagas' Disease Cardiomyopathy	2005
ACADVL	acyl-CoA dehydrogenase very long chain	acyl-Coenzyme A dehydrogenase, very long chain, nuclear gene encoding mitochondrial protein	ENSG00000072778	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	None	No	Microarray	No	None	None	None	Homo sapiens	Brazil	None	16049318	10.1016/S0002-9440(10)62976-8	Cardiac Gene Expression Profiling Provides Evidence for Cytokinopathy as a Molecular Mechanism in Chagas' Disease Cardiomyopathy	2005
ACTA1	actin alpha 1, skeletal muscle	Alpha cardiac muscle actin	ENSG00000143632	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	None	No	Microarray	No	None	None	None	Homo sapiens	Brazil	None	16049318	10.1016/S0002-9440(10)62976-8	Cardiac Gene Expression Profiling Provides Evidence for Cytokinopathy as a Molecular Mechanism in Chagas' Disease Cardiomyopathy	2005

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