ChagasDB

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Feature name Feature description Feature name in paper Feature ID Feature type Feature variation Phenotype 1 Description phenotype 1 Phenotype 2 Description phenotype 2 Tissue Tissue description Experimental Method Interaction observed Name of the interactive features ID of the interactive features Type of interactive feature Organism Population T.cruzi strain Paper PMID Paper DOI Paper title Paper date
Feature name Feature description Feature name in paper Feature ID Feature type Feature variation Phenotype 1 Description phenotype 1 Phenotype 2 Description phenotype 2 Tissue Tissue description Experimental Method Interaction observed Name of the interactive features ID of the interactive features Type of interactive feature Organism Population T.cruzi strain Paper PMID Paper DOI Paper title Paper date
GPX1 glutathione peroxidase 1 ENSG00000233276 RNA DOWN Mild cardiac Mild cardiac impairmentsvg Healthy None Blood None Yes GSH/NADPH/GR system No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
GPX1 glutathione peroxidase 1 ENSG00000233276 RNA DOWN Moderate cardiac Moderate cardiac impairmentsvg Healthy None Blood None Yes GSH/NADPH/GR system No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
GSS glutathione synthetase ENSG00000100983 RNA UP Asymptomatic Nonesvg Healthy None Blood None Yes Elmann's reagent No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
GSS glutathione synthetase ENSG00000100983 RNA UP Mild cardiac Mild cardiac impairmentsvg Healthy None Blood None Yes Elmann's reagent No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
GSS glutathione synthetase ENSG00000100983 RNA UP Moderate cardiac Moderate cardiac impairmentsvg Healthy None Blood None Yes Elmann's reagent No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
GSSG GSSG None Chemical molecule UP Asymptomatic Nonesvg Healthy None Blood None Yes Glutatione and reduced glutathione difference No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
GSTP1 glutathione S-transferase pi 1 ENSG00000084207 Protein UP Asymptomatic Nonesvg Healthy None Blood None Yes GSH concentration No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
GSTP1 glutathione S-transferase pi 1 ENSG00000084207 Protein UP Moderate cardiac Moderate cardiac impairmentsvg Healthy None Blood None Yes GSH concentration No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
IL12B interleukin 12B None Polymorphism UP Cardiac Nonesvg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Colombia None 17644387 10.1016/j.micinf.2007.04.010 Polymorphism in the 3' UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy 2007
IL15 interleukin 15 ENSG00000164136 Protein UP Cardiac Nonesvg Healthy None Heart Right ventricle Yes immunohistochemical analysis No None None None Homo sapiens Brazil None 17635814 10.1111/j.1365-3083.2007.01987.x Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy 2007
LTA lymphotoxin alpha rs909253 Polymorphism UP Cardiac Nonesvg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 18190265 10.1086/523653 Polymorphisms in the gene for lymphotoxin-alpha predispose to chronic Chagas cardiomyopathy 2007
NFKBIL1 NFKB Inhibitor Like 1 None Polymorphism UP Cardiac Nonesvg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 17544510 10.1016/j.molimm.2007.04.015 Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals 2007
NFKBIL1 NFKB Inhibitor Like 1 None Polymorphism UP Cardiac Nonesvg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 17544510 10.1016/j.molimm.2007.04.015 Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals 2007
NFKBIL1 NFKB Inhibitor Like 1 None Polymorphism UP Moderate cardiac EF > 0.4svg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 17544510 10.1016/j.molimm.2007.04.015 Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals 2007
NFKBIL1 NFKB Inhibitor Like 1 None Polymorphism UP Moderate cardiac EF > 0.4svg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 17544510 10.1016/j.molimm.2007.04.015 Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals 2007
NFKBIL1 NFKB Inhibitor Like 1 None Polymorphism UP Severe cardiac EF <= 0.4svg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 17544510 10.1016/j.molimm.2007.04.015 Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals 2007
Nitricoxide Nitric oxide None Chemical molecule UP Acute 5 dpisvg Healthy None Splenocyte None Yes NaNO2 concentration No None None None Mus musculus Balb/c Y strain 17286971 10.1016/j.exppara.2006.12.007 DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi 2007
SOD1 superoxide dismutase 1 ENSG00000142168 RNA UP Mild cardiac Mild cardiac impairmentsvg Healthy None Blood None Yes Epinephrine autoxidation No None None None Homo sapiens Brazil None 16859784 10.1016/j.ijcard.2006.04.046 Oxidative stress in chronic cardiopathy associated with Chagas disease 2007
CCL2 C-C motif chemokine ligand 2 None Polymorphism UP Cardiac Nonesvg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 16804844 10.1086/505395 The monocyte chemoattractant protein-1 gene polymorphism is associated with cardiomyopathy in human chagas disease 2006
CCL2 C-C motif chemokine ligand 2 None Polymorphism UP Moderate cardiac EF > 0.4svg Asymptomatic None Blood None Yes PCR No None None None Homo sapiens Brazil None 16804844 10.1086/505395 The monocyte chemoattractant protein-1 gene polymorphism is associated with cardiomyopathy in human chagas disease 2006
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