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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Tgfb1	transforming growth factor, beta 1 [Source:MGI Symbol;Acc:MGI:98725]	TGF-Î²	ENSMUSG00000002603	RNA	UP	Acute	7 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tgfb1	transforming growth factor, beta 1 [Source:MGI Symbol;Acc:MGI:98725]	TGF-Î²	ENSMUSG00000002603	RNA	UP	Acute	14 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tgfb1	transforming growth factor, beta 1 [Source:MGI Symbol;Acc:MGI:98725]	TGF-Î²	ENSMUSG00000002603	RNA	UP	Acute	21 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tgfb1	transforming growth factor, beta 1 [Source:MGI Symbol;Acc:MGI:98725]	TGF-Î²	ENSMUSG00000002603	RNA	UP	Acute	28 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tgfb1	transforming growth factor, beta 1 [Source:MGI Symbol;Acc:MGI:98725]	TGF-Î²	ENSMUSG00000002603	RNA	UP	Acute	42 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Timp1	tissue inhibitor of metalloproteinase 1 [Source:MGI Symbol;Acc:MGI:98752]	TIMP-1	ENSMUSG00000001131	RNA	UP	Acute	14 dpisvg	Healthy	None	Heart	None	Yes	PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18444803	10.1086/587487	Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection	2008
Timp1	tissue inhibitor of metalloproteinase 1 [Source:MGI Symbol;Acc:MGI:98752]	TIMP-1	ENSMUSG00000001131	RNA	UP	Acute	20 dpisvg	Healthy	None	Heart	None	Yes	PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18444803	10.1086/587487	Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection	2008
Timp3	tissue inhibitor of metalloproteinase 3 [Source:MGI Symbol;Acc:MGI:98754]	TIMP-3	ENSMUSG00000020044	RNA	UP	Acute	3 dpisvg	Healthy	None	Heart	None	Yes	PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18444803	10.1086/587487	Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	7 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	BALB/c	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	14 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	BALB/c	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	21 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	BALB/c	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	28 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	BALB/c	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	42 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	BALB/c	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	7 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	14 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	21 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	28 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
Tnf	tumor necrosis factor [Source:MGI Symbol;Acc:MGI:104798]	TNF-Î±	ENSMUSG00000024401	RNA	UP	Acute	42 dpisvg	Healthy	None	Heart	None	Yes	qRT-PCR	No	None	None	None	Mus musculus	C57BL/6	Y strain	18473687	10.1086/529527	Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages	2008
CAT	catalase	CAT	ENSG00000121691	RNA	UP	Asymptomatic	Nonesvg	Healthy	None	Blood	None	Yes	Hydrogen peroxide solution	No	None	None	None	Homo sapiens	Brazil	None	16859784	10.1016/j.ijcard.2006.04.046	Oxidative stress in chronic cardiopathy associated with Chagas disease	2007
CD68	CD68 molecule	CD68	ENSG00000129226	Protein	UP	Cardiac	Nonesvg	Healthy	None	Heart	Right ventricle	Yes	immunohistochemical analysis	No	None	None	None	Homo sapiens	Brazil	None	17635814	10.1111/j.1365-3083.2007.01987.x	Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy	2007

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