ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
THUMPD3	THUMP domain containing 3	THUMPD3	ENSG00000134077	RNA	DOWN	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
THYN1	thymocyte nuclear protein 1	THYN1	ENSG00000151500	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIA1	TIA1 cytotoxic granule associated RNA binding protein	TIA1	ENSG00000116001	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1	TIAL1	ENSG00000151923	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TICAM2	TIR domain containing adaptor molecule 2	TICAM2	ENSG00000243414	RNA	DOWN	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIGD1	tigger transposable element derived 1	TIGD1	ENSG00000221944	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIMM21	translocase of inner mitochondrial membrane 21	C18orf55	ENSG00000075336	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIMM21	translocase of inner mitochondrial membrane 21	C18orf55	ENSG00000075336	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIMM21	translocase of inner mitochondrial membrane 21	C18orf55	ENSG00000075336	RNA	DOWN	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIMM23	translocase of inner mitochondrial membrane 23	TIMM23	ENSG00000265354	RNA	UP	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIMM44	translocase of inner mitochondrial membrane 44	TIMM44	ENSG00000104980	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
Timp1	tissue inhibitor of metalloproteinase 1 [Source:MGI Symbol;Acc:MGI:98752]	Timp1	ENSMUSG00000001131	RNA	UP	Acute	39h dpisvg	Healthy	None	Cardiomyocytes	None	No	Microarray	No	None	None	None	Mus musculus	None	Y strain	19729072	10.1016/j.micinf.2009.08.009	Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes	2009
Timp3	tissue inhibitor of metalloproteinase 3 [Source:MGI Symbol;Acc:MGI:98754]	Timp3	ENSMUSG00000020044	RNA	DOWN	Acute	44h dpisvg	Healthy	None	Cardiomyocytes	None	No	Microarray	No	None	None	None	Mus musculus	None	Y strain	19729072	10.1016/j.micinf.2009.08.009	Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes	2009
TINF2	TERF1 interacting nuclear factor 2	TINF2	ENSG00000092330	RNA	UP	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TINF2	TERF1 interacting nuclear factor 2	TINF2	ENSG00000092330	RNA	UP	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIPARP	TCDD inducible poly(ADP-ribose) polymerase	TIPARP	ENSG00000163659	RNA	UP	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
TIRAP	TIR domain containing adaptor protein	MAL/TIRAP S180L	rs8177374	Polymorphism	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	Yes	PCR RFLP	No	None	None	None	Homo sapiens	Brazil	None	19456234	10.1086/599212	Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy	2009
TIRAP	TIR domain containing adaptor protein	MAL/TIRAP S180L	rs8177374	Polymorphism	UP	Moderate cardiac	> 0.4svg	Asymptomatic	None	Blood	None	Yes	PCR RFLP	No	None	None	None	Homo sapiens	Brazil	None	19456234	10.1086/599212	Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy	2009
TIRAP	TIR domain containing adaptor protein	MAL/TIRAP S180L	rs8177374	Polymorphism	UP	Severe cardiac	<= 0.4svg	Asymptomatic	None	Blood	None	Yes	PCR RFLP	No	None	None	None	Homo sapiens	Brazil	None	19456234	10.1086/599212	Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy	2009
TLCD2	TLC domain containing 2	241359_at	ENSG00000185561	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009

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