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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
HELZ	helicase with zinc finger	HELZ	ENSG00000198265	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HELZ	helicase with zinc finger	HELZ	ENSG00000198265	RNA	DOWN	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HELZ2	helicase with zinc finger 2	PRIC285	ENSG00000130589	RNA	UP	Acute	24h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HELZ2	helicase with zinc finger 2	PRIC285	ENSG00000130589	RNA	UP	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HELZ2	helicase with zinc finger 2	PRIC285	ENSG00000130589	RNA	UP	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HEMK1	HemK methyltransferase family member 1	HEMK1	ENSG00000114735	RNA	DOWN	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HEMK1	HemK methyltransferase family member 1	HEMK1	ENSG00000114735	RNA	DOWN	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	HERC1	ENSG00000103657	RNA	DOWN	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	HERC5	ENSG00000138646	RNA	UP	Acute	24h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	HERC5	ENSG00000138646	RNA	UP	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	HERC5	ENSG00000138646	RNA	UP	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	HERC5	ENSG00000138646	RNA	UP	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC6	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	HERC6	ENSG00000138642	RNA	UP	Acute	24h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC6	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	HERC6	ENSG00000138642	RNA	UP	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC6	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	HERC6	ENSG00000138642	RNA	UP	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HERC6	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	HERC6	ENSG00000138642	RNA	UP	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HES4	hes family bHLH transcription factor 4	HES4	ENSG00000188290	RNA	UP	Acute	24h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HES4	hes family bHLH transcription factor 4	HES4	ENSG00000188290	RNA	UP	Acute	24h pisvg	Healthy	None	Human foreskin fibroblasts (HFF)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HES4	hes family bHLH transcription factor 4	HES4	ENSG00000188290	RNA	UP	Acute	24h pisvg	Healthy	None	Human cardiac microvascular endothelial cells (HMVEC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009
HES4	hes family bHLH transcription factor 4	HES4	ENSG00000188290	RNA	UP	Acute	48h pisvg	Healthy	None	Vascular smooth muscle cells (VSMC)	None	No	Microarray	No	None	None	None	Homo sapiens	None	Y strain	19480704	10.1186/1471-2164-10-252	Cytokine-dependent and-independent gene expression changes and cell cycle block revealed in Trypanosoma cruzi-infected host cells by comparative mRNA profiling	2009

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