ChagasDB

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Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
Feature name	Feature description	Feature name in paper	Feature ID	Feature type	Feature variation	Phenotype 1	Description phenotype 1	Phenotype 2	Description phenotype 2	Tissue	Tissue description	Experimental	Method	Interaction observed	Name of the interactive features	ID of the interactive features	Type of interactive feature	Organism	Population	T.cruzi strain	Paper PMID	Paper DOI	Paper title	Paper date
DOCK9	dedicator of cytokinesis 9	DOCK9	cg16624069	Methylation	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOCK9	dedicator of cytokinesis 9	DOCK9	cg20132609	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOCK9	dedicator of cytokinesis 9	DOCK9	cg24586978	Methylation	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOCK9	dedicator of cytokinesis 9	DOCK9	cg27518324	Methylation	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK1	docking protein 1	DOK1	cg09116068	Methylation	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg21031128	Methylation	DOWN	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	ENSG00000147443	RNA	None	Cardiac	Nonesvg	Cardiac	None	Heart	Left ventricule	No	TFBS enrichment in JASPAR database	Yes	IRF4	ENSG00000137265	TFBS	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	ENSG00000147443	RNA	None	Cardiac	Nonesvg	Cardiac	None	Heart	Left ventricule	No	TFBS enrichment in JASPAR database	Yes	RUNX3	ENSG00000020633	TFBS	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	ENSG00000147443	RNA	None	Cardiac	Nonesvg	Cardiac	None	Heart	Left ventricule	No	TFBS enrichment in JASPAR database	Yes	TBX21	ENSG00000073861	TFBS	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg00255726	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg00443121	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg08288130	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg14386061	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg16476235	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg21163717	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	cg24969098	Methylation	DOWN	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK2	docking protein 2	DOK2	ENSG00000147443	RNA	UP	Cardiac	Nonesvg	Healthy	None	Heart	Left ventricule	No	RNA-seq	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK3	docking protein 3	DOK3	cg25429578	Methylation	UP	Cardiac	Nonesvg	Asymptomatic	None	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK3	docking protein 3	DOK3	cg06534800	Methylation	DOWN	Severe cardiac	LVEF < 40%svg	Moderate cardiac	LVEF >= 40%	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022
DOK4	docking protein 4	DOK4	cg20142224	Methylation	UP	Severe cardiac	LVEF < 40%svg	Moderate cardiac	LVEF >= 40%	Blood	None	No	EPIC Illumina	No	None	None	None	Homo sapiens	Brazil	None	36072583	10.3389/fimmu.2022.958200	Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy	2022

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